SULFASALAZINE REDUCES PLACENTAL SECRETION OF ANTIANGIOGENIC FACTORS, UP-REGULATES THE SECRETION OF PLACENTAL GROWTH FACTOR AND RESCUES ENDOTHELIAL DYSFUNCTIONRESEARCH IN CONTEXT

Background: Preeclampsia is a major complication of pregnancy with no medical treatment.It is associated with placental oxidative stress, hypoxia and inflammation leading to soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion and reduced placental growth factor (PlGF).This results in widespread endothelial dysfunction

Hox proteins are conserved homeodomain transcription factors known to be crucial regulators of animal development.As transcription factors, the functions and ReAction modes of action (co-factors, target genes) of Hox proteins have been very well studied in a multitude of animal models.However, a handful of reports established that Hox proteins may

Acute cerebellar ataxia (ACA) is a self-limited syndrome that is frequently post-infectious, most commonly following Varicella infection having an autoimmune mechanism.ACA is the commonest cause of childhood ataxia.We report a 14-year-old male who presented with Fairy Wings acute onset wide-based gait and slurring of speech with dysdiadochokinesia,

The dynamic of pairwise correlations, including quantum entanglement (QE) and discord (QD) with geometric measure of quantum discord (GMQD), are shown in the four-qubit Heisenberg XX spin chain.The results show that the Spirdust effect of the entanglement degree of the initial state on the pairwise correlations is stronger for alternate qubits than

Reductions in response control (greater reaction time variability and commission error rate) are consistently observed in those diagnosed with attention-deficit/hyperactivity disorder (ADHD).Previous research suggests these reductions arise from a dysregulation of large-scale cortical networks.Here, we extended our understanding of this cortical-ne